How RIG-I like receptors activate MAVS
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چکیده
منابع مشابه
How RIG-I like receptors activate MAVS.
RIG-I and MDA5 are well-conserved cytoplasmic pattern recognition receptors that detect viral RNAs during infection and activate the type I interferon (IFN)-mediated antiviral immune response. While much is known about how these receptors recognize viral RNAs, how they interact with their common signaling adaptor molecule MAVS and activate the downstream signaling pathway had been less clear. P...
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In mammalian cells, the first line of defense against viral pathogens is the innate immune response, which is characterized by induction of type I interferons (IFN) and other pro-inflammatory cytokines that establish an antiviral milieu both in infected cells and in neighboring uninfected cells. Rotavirus, a double-stranded RNA virus of the Reoviridae family, is the primary etiological agent of...
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Initiating the immune response to invading pathogens, the innate immune system is constituted of immune receptors (pattern recognition receptors, PRR) that sense microbe-associated molecular patterns (MAMPs). Detection of pathogens triggers intracellular defense mechanisms, such as the secretion of cytokines or chemokines to alarm neighboring cells and attract or activate immune cells. The inna...
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ژورنال
عنوان ژورنال: Current Opinion in Virology
سال: 2015
ISSN: 1879-6257
DOI: 10.1016/j.coviro.2015.04.004